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Patterns of diastolic dysfunction in left ventricular hypertrophy.

L M Shapiro1, D G Gibson

  • 1National Heart Hospital, London.

British Heart Journal
|April 1, 1988
PubMed
Summary
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Different measurements of diastolic function were assessed in patients with left ventricular hypertrophy. The study found at least four distinct abnormalities, suggesting no single underlying cause for diastolic dysfunction.

Area of Science:

  • Cardiology
  • Echocardiography
  • Diastolic Function Assessment

Background:

  • Left ventricular hypertrophy (LVH) can impact cardiac diastolic function.
  • Assessing diastolic dysfunction requires understanding various physiological parameters.

Purpose of the Study:

  • To compare the sensitivity and interrelations of different diastolic function measurements in LVH patients.
  • To identify distinct patterns of diastolic dysfunction in LVH.

Main Methods:

  • Digitized M-mode echocardiography, Doppler echocardiography, and apexcardiography were used.
  • Measurements included isovolumic relaxation time, filling intervals, and velocity parameters.
  • Data from 50 LVH patients were compared to 20 age-matched controls.

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Main Results:

  • Most diastolic function measurements were significantly different in LVH patients compared to controls.
  • The 'a' wave height on apexcardiogram was the most sensitive indicator; peak dimension increase rate was least sensitive.
  • Correlations between parameters were weak, suggesting independent physiological bases.

Conclusions:

  • Abnormal diastolic function in LVH is not a single entity but comprises at least four discrete abnormalities.
  • These include prolonged isovolumic relaxation, incoordination, reduced rapid filling, and increased 'a' wave amplitude.
  • These abnormalities can occur individually or in combination.