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Inhibition of the inductive activity of demineralized bone matrix by different percutaneous implants
G Uretzky1, J Appelbaum, J Sela
1Joseph Lunenfeld Cardiac Surgery Research Center, Hadassah University Hospital, Jerusalem, Israel.
Biomaterials
|March 1, 1988
Abstract:
Teflon tubes with either Gore-Tex (PTFE) or Dacron felt sleeves were implanted percutaneously in rats, in conjunction with demineralized bone matrix. This resulted in different inflammatory reactions, as well as in chondrogenesis and osteogenesis in the subcutaneous tissues. Although induction of osteogenesis by the demineralized bone matrix in the vicinity of the foreign material was inhibited, circumferential bone formation was highly reproducible. The prospect of utilizing demineralized bone matrix in order to enhance acceptance of percutaneous tubes is discussed.