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Morphine does not stimulate prolactin release during lactation.

P Callahan1, J Janik, L Grandison

  • 1Department of Biological Sciences, Rutgers University, Piscataway, NJ 08855.

Brain Research
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

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Morphine stimulates prolactin and growth hormone (GH) release in most rats, but not lactating females. Suckling may cause this refractoriness, potentially via mu-opiate receptor changes.

Area of Science:

  • Neuroendocrinology
  • Reproductive Biology
  • Pharmacology

Background:

  • Opioid agonists like morphine influence hormone release.
  • Prolactin and growth hormone (GH) regulation is complex and varies with physiological state.

Purpose of the Study:

  • To investigate the effect of morphine on prolactin and GH release in male and female rats across different reproductive stages.
  • To determine if lactation alters the response to morphine and other opioid agonists.

Main Methods:

  • Administered morphine and other opioid agonists (beta-endorphin, DADLE) to male and female rats (diestrus, proestrus, lactation).
  • Measured circulating prolactin and GH levels.
  • Administered haloperidol to lactating rats to assess dopaminergic neuron function.

Related Experiment Videos

Main Results:

  • Morphine increased prolactin in males and non-lactating females but not in lactating dams.
  • Haloperidol stimulated prolactin release in lactating rats, indicating functional dopaminergic pathways.
  • Morphine, beta-endorphin, and DADLE stimulated GH release in all groups, including lactating females.
  • Lactating rats were insensitive to morphine's prolactin-releasing effect but responsive to other opioid agonists for GH release.

Conclusions:

  • The suckling stimulus during lactation induces refractoriness to morphine-induced prolactin release.
  • This refractoriness may be due to down-regulation of mu-opiate receptors.
  • Opioid agonists continue to stimulate GH release during lactation.