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Infantile Spasms-Have We Made Progress?

Sarah Aminoff Kelley1, Kelly G Knupp2

  • 1Johns Hopkins Hospital, 600 N. Wolfe St., Meyer 2-147, Baltimore, MD, 21287, USA.

Current Neurology and Neuroscience Reports
|April 20, 2018
PubMed
Summary
This summary is machine-generated.

Early diagnosis and treatment with standard medications like hormonal therapy or vigabatrin are crucial for infants with infantile spasms. Combination therapy shows promise for initial treatment, improving short-term outcomes.

Keywords:
ACTHEpileptic spasmsHypsarrhythmiaInfantile spasmsVigabatrinWest syndrome

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Area of Science:

  • Pediatric Neurology
  • Epileptology

Background:

  • Infantile spasms management presents ambiguities despite existing guidelines.
  • Recent research offers new insights into treatment strategies.

Purpose of the Study:

  • To provide an updated review on the current care of children diagnosed with infantile spasms.
  • To address ambiguities in infantile spasms management.

Main Methods:

  • Review of recent studies and randomized trials.
  • Analysis of data guiding infantile spasms management.

Main Results:

  • Combination therapy (hormone treatment and vigabatrin) is supported as an initial treatment.
  • Early diagnosis and prompt treatment with hormonal therapy (ACTH or prednisolone) or vigabatrin significantly impact short-term outcomes.
  • The diagnostic value of hypsarrhythmia recognition may be inconsistent or lack predictive value.

Conclusions:

  • Early diagnosis and treatment are paramount for improving outcomes in infantile spasms.
  • Standard medications like hormonal therapy and vigabatrin remain key treatment options.
  • Further research may clarify the role of hypsarrhythmia in prognosis.