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Infantile Spasms-Have We Made Progress?

Sarah Aminoff Kelley1, Kelly G Knupp2

  • 1Johns Hopkins Hospital, 600 N. Wolfe St., Meyer 2-147, Baltimore, MD, 21287, USA.

Current Neurology and Neuroscience Reports
|April 20, 2018
PubMed

Insights

Early diagnosis and treatment with standard medications like hormonal therapy or vigabatrin are crucial for infants with infantile spasms. Combination therapy shows promise for initial treatment, improving short-term outcomes.

Area of Science:

  • Pediatric Neurology
  • Epileptology

Background:

  • Infantile spasms management presents ambiguities despite existing guidelines.
  • Recent research offers new insights into treatment strategies.

Purpose of the Study:

  • To provide an updated review on the current care of children diagnosed with infantile spasms.
  • To address ambiguities in infantile spasms management.

Main Methods:

  • Review of recent studies and randomized trials.
  • Analysis of data guiding infantile spasms management.

Main Results:

  • Combination therapy (hormone treatment and vigabatrin) is supported as an initial treatment.
  • Early diagnosis and prompt treatment with hormonal therapy (ACTH or prednisolone) or vigabatrin significantly impact short-term outcomes.
  • The diagnostic value of hypsarrhythmia recognition may be inconsistent or lack predictive value.

Conclusions:

  • Early diagnosis and treatment are paramount for improving outcomes in infantile spasms.
  • Standard medications like hormonal therapy and vigabatrin remain key treatment options.
  • Further research may clarify the role of hypsarrhythmia in prognosis.
Abstract

Keywords:
ACTHEpileptic spasmsHypsarrhythmiaInfantile spasmsVigabatrinWest syndrome

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