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Calcium and Nuclear Signaling in Prostate Cancer

Ivan V Maly1, Wilma A Hofmann2

  • 1Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 955 Main Street, Buffalo, NY 14203, USA. ivanmaly@buffalo.edu.

International Journal of Molecular Sciences
|April 20, 2018
PubMed

Insights

New insights into calcium and nuclear signaling offer novel diagnostic and treatment strategies for prostate cancer. Understanding molecular mechanisms driving cancer progression and treatment resistance is key.

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Signaling

Background:

  • Prostate cancer diagnosis and treatment face challenges, particularly in managing malignant progression and resistance to anti-androgen therapies.
  • Recent advancements in understanding calcium and nuclear signaling pathways have revealed potential new therapeutic targets.

Purpose of the Study:

  • To review current developments in calcium and nuclear signaling.
  • To identify unifying themes relevant to prostate cancer diagnosis and treatment.
  • To explore molecular mechanisms underlying prostate cancer progression and treatment resistance.

Main Methods:

  • Literature review focusing on calcium signaling, nuclear import, and nuclear calcium signaling.
  • Analysis of genomic perturbations, kinase cascades, developmental pathways, and channels/transporters.
  • Emphasis on nuclear transport and functions in prostate cancer.

Main Results:

  • Discovery of new molecular classes (GPCRs, myosin) involved in calcium-regulated nuclear processes.
  • Identification of key pathways (genomic, kinase, developmental, transport) implicated in prostate cancer.
  • Detailed examination of mechanisms driving malignant progression and anti-androgen treatment failure.

Conclusions:

  • Unifying themes in calcium and nuclear signaling offer promising avenues for prostate cancer management.
  • New hypotheses connecting disparate findings may lead to translational applications.
  • Further research into these signaling pathways could improve diagnostic and therapeutic outcomes for prostate cancer.
Keywords:
calciummetastasismyosin ICnuclear importprostate cancer

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