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Initial Management of Colonic Diverticular Bleeding: Observational Study
Michiko Wada1,2, Motohiko Kato1, Yuichiro Hirai1
1Department of Gastroenterology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
Insights
Identifying the source of colonic diverticular bleeding (CDB) is key to preventing re-bleeding. Urgent colonoscopy guided by CT scans can significantly improve outcomes for patients with CDB, especially those with a history of the condition or chronic kidney disease.
Area of Science:
- Gastroenterology
- Endoscopy
- Radiology
Background:
- Colonic diverticular bleeding (CDB) frequently stops spontaneously, but re-bleeding affects approximately 30% of patients.
- Endoscopic hemostasis offers direct treatment for bleeding diverticula, yet its application is limited by resource constraints and procedural risks.
- Determining optimal colonoscopy candidates and initial management strategies for CDB is crucial.
Purpose of the Study:
- To identify risk factors for re-bleeding in patients with CDB.
- To determine factors influencing the identification of the bleeding source during colonoscopy.
- To establish appropriate initial management and colonoscopy indications for CDB patients.
Main Methods:
- Retrospective analysis of 285 patients diagnosed with CDB who underwent colonoscopy between March 2004 and October 2015.
- Statistical analysis to correlate re-bleeding with patient background and initial management.
- Evaluation of examination conditions affecting bleeding point identification.
Main Results:
- Re-bleeding occurred in 28% of patients.
- A history of CDB (OR 2.1) and chronic kidney disease (CKD; OR 2.3) were identified as risk factors for re-bleeding.
- Bleeding point identification, achieved in 70% of patients with CT-detected extravasation undergoing urgent colonoscopy, significantly reduced re-bleeding by approximately 80% (OR 0.20).
Conclusions:
- Contrast-enhanced CT upon patient arrival is recommended for evaluating CDB.
- Patients with CT-identified extravasation, a history of CDB, or CKD are strong candidates for urgent colonoscopy.
- Successful identification of the bleeding source during colonoscopy is a critical factor in preventing recurrent bleeding.
Background/Aims:
Although colonic diverticular bleeding (CDB) often ceases spontaneously, re-bleeding occurs in about 30%. Bleeding diverticulum can be treated directly by endoscopic hemostasis; however, it is difficult to perform colonoscopy in all cases with limited medical resource and certain risks. The aim of this study was to clarify who should undergo colonoscopy as well as appropriate methods of initial management in CDB patients.
Methods:
A total of 285 patients who were diagnosed as CDB and underwent colonoscopy from March 2004 to October 2015 were retrospectively analyzed. First, the association between re-bleeding and various factors including patients' background and initial management were analyzed. Second, the examination conditions that influenced bleeding point identification were analyzed.
Results:
Of 285 patients, 187 were men and 98 were women. Median age was 75 years, and the median observation period was 17.5 months. Re-bleeding was observed in 79 patients (28%). A history of CDB (OR 2.1, p = 0.0090) and chronic kidney disease (CKD; OR 2.3, p = 0.035) were risk factors, and bleeding point identification (OR 0.20, p = 0.0037) was a preventive factor for re-bleeding. Bleeding point identification significantly reduced approximately 80% of re-bleeding. Furthermore, extravasation on CT (OR 3.7, p = 0.031) and urgent colonoscopy (OR 5.3, p < 0.001) were predictors for identification of bleeding point. Compared to bleeding point identification of 11% in all patients who underwent colonoscopy, identification rate in those who had extravasation on CT and underwent urgent colonoscopy was as high as 70%.
Conclusions:
Contrast-enhanced CT upon arrival is suggested, and patients with extravasation on CT would be good candidates for urgent colonoscopy, as well as patients who have a history of CDB and CKD.
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