Related Experiment Video

Updated: Feb 11, 2026

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
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Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Published on: August 1, 2018

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Predictive Factors of Portal Hypertensive Enteropathy Exacerbation in Patients with Liver Cirrhosis: A Capsule

Sayoko Kunihara1, Shiro Oka1, Shinji Tanaka2

  • 1Department of Gastroenterology and Metabolism, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

Digestion
|April 20, 2018
PubMed

Insights

Exacerbation of esophageal varices and portal hypertensive gastropathy may predict worsening of portal hypertensive enteropathy in liver cirrhosis patients. This finding aids in understanding disease progression.

Area of Science:

  • Gastroenterology
  • Hepatology
  • Endoscopy

Background:

  • Portal hypertensive enteropathy (PHE) clinical course and exacerbation require further clarification.
  • Identifying factors associated with PHE exacerbation in liver cirrhosis (LC) patients is crucial for management.

Purpose of the Study:

  • To identify clinical factors related to the exacerbation of portal hypertensive enteropathy (PHE) in patients with liver cirrhosis (LC).

Main Methods:

  • Fifty liver cirrhosis patients underwent capsule endoscopy (CE) and were followed for over six months.
  • Exacerbation was defined by new or worsening lesions; associations with clinical factors were evaluated.
  • Multivariate analysis identified independent predictors of PHE exacerbation.

Main Results:

  • PHE exacerbation occurred in 48% of patients, with erythema and angioectasia being common.
  • Factors significantly associated with PHE exacerbation included portosystemic shunts, esophageal varices (EVs), and portal hypertensive gastropathy (PHG) exacerbation.
  • Exacerbation of EVs and PHG were independent predictors of PHE exacerbation on multivariate analysis.

Conclusions:

  • Exacerbation of esophageal varices and portal hypertensive gastropathy are potential predictors of portal hypertensive enteropathy exacerbation in liver cirrhosis patients.
  • These findings contribute to a better understanding of PHE progression and management strategies in LC.
Abstract

Keywords:
Portal hypertensive enteropathyCapsule endoscopyEsophageal varicesLiver cirrhosisPortal hypertensive gastropathy

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