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Updated: Feb 11, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Anaphylactic Reactions to Native and Light-Exposed Sugammadex Suggested by Basophil Activation Test: A Report of 2
Takashige Yamada1, Takeshi Suzuki, Reiko Murase
1From the Department of Anesthesiology, Keio University School of Medicine, Tokyo, Japan.
Abstract:
We describe 2 patients who developed anaphylactic shock after sugammadex administration during anesthesia. Both had no history of prior sugammadex administration. The serum tryptase concentrations were elevated after the allergic reaction. Basophil activation testing 1 month after the events was positive for sugammadex in 1 patient, and negative in the other. However, it was positive for light-exposed sugammadex solution in both patients, suggesting a possible allergic reaction to a denatured compound of sugammadex generated by light exposure of the sugammadex solution.
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