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Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
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Cirrhotic Cardiomyopathy After Transplantation: Neither the Transient Nor Innocent Bystander

Manhal Izzy1, Jae Oh2, Kymberly D Watt1

  • 1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.

Hepatology (Baltimore, Md.)
|April 20, 2018
PubMed

Insights

Cirrhotic cardiomyopathy in end-stage liver disease shows limited evidence of reversal after liver transplantation (LT). Updated diagnostic criteria are needed to better evaluate post-LT outcomes and risks.

Area of Science:

  • Cardiology
  • Hepatology
  • Transplantation Medicine

Background:

  • Cirrhotic cardiomyopathy (CC) is defined by impaired cardiac function in end-stage liver disease without other cardiac causes.
  • Established in 2005, CC diagnostic criteria have been extensively studied regarding pathophysiology and pre-transplant course.
  • Post-transplant data on CC are limited, necessitating a review of its impact after liver transplantation (LT).

Purpose of the Study:

  • To review the post-transplant course and prognosis of cirrhotic cardiomyopathy elements following liver transplantation.
  • To assess the reversibility of CC after LT.
  • To highlight the need for updated diagnostic criteria for CC.

Main Methods:

  • Literature review focusing on studies examining cirrhotic cardiomyopathy post-liver transplantation.
  • Analysis of existing data on the pathophysiology and clinical course of CC.
  • Evaluation of echocardiographic advancements in assessing cardiac dysfunction.

Main Results:

  • Limited evidence suggests CC is not readily reversible after LT.
  • CC may elevate the risk of post-transplant complications.
  • Significant advancements in echocardiography warrant refinement of CC diagnostic criteria.

Conclusions:

  • The reversibility of cirrhotic cardiomyopathy after liver transplantation remains poorly demonstrated.
  • Updated diagnostic criteria for CC are crucial for accurate assessment of post-transplant outcomes.
  • Refined criteria will improve the evaluation of CC-related risks and complications in liver transplant recipients.

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