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Published on: March 12, 2020
The polypharmacology of natural products
Tu T Ho1, Quy Tn Tran1, Christina Ll Chai1
1Department of Pharmacy, 18 Science Drive 4, Faculty of Science, National University of Singapore, Singapore 117543.
Abstract:
The once-popular approach of using natural products as a prime source for medicinal chemistry and drug discovery has waned considerably in the past two decades due to the advent of high-throughput screening of small molecule mega libraries. However, the growing appreciation of network pharmacology as the next drug-discovery paradigm suggests that natural products and their unique polypharmacology offer significant advantages for finding novel therapeutics particularly for the treatment of complex and multifactorial diseases. Drug discovery process is awaiting the revitalization of interest in natural products and their derivatives. The current challenge is how to decipher this natural chemical diversity.
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