Related Experiment Video
Updated: Feb 11, 2026

A Simple Flow Cytometric Method to Measure Glucose Uptake and Glucose Transporter Expression for Monocyte Subpopulations in Whole Blood
Published on: August 12, 2016
Sodium Glucose Co-Transporter 2 Inhibitors: Beyond Glucose Lowering
1Medical Pharmacology, Ankara Yildirim Beyazit University, School of Medicine, Ankara 06010, Turkey and Center for cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, United States.
Abstract:
Diabetes is an important cause of morbidity and mortality worldwide. Management of blood glucose is critical for diabetic patients since diabetes carries a risk for many diseases and disorders. Although there are several antidiabetic agents in the markets for a long time, some of the agents have dose-limiting side effects, such as hypoglycemia and weight gain which limits their ability to reduce cardiovascular complications. Sodium-glucose co-transporter 2 (SGLT2) inhibitors are a new class of antidiabetic agents which exerts their effects insulin-independent mechanism, therefore, they do not cause hypoglycemia in the diabetic patients. Due to the unique class-dependent mechanism, they can be adjunct to the standard therapy of the diabetic patients. Recent studies have speculated that SGLT2 inhibitors have some beneficial effects other than hypoglycemic effects in diabetic patients like lowering body weight, reducing blood pressure and hyperuricemia. This review aims to discuss the pleiotropic effects of SGLT2 inhibitors and gives an avenue for new research ideas.
Related Concept Videos
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
Glucose Absorption Into the Small Intestine
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
Secondary Active Transport
Vapor Pressure Lowering

