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Brain Imaging Using Hyperpolarized 129Xe Magnetic Resonance Imaging.

Simrun Chahal1, Braedan R J Prete1, Alanna Wade1

  • 1Lakehead University, Thunder Bay, ON, Canada.

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Hyperpolarized 129-Xenon (HP 129Xe) MRI offers a new way to image the brain. This study details protocols for using HP 129Xe MRI to visualize brain structures in both rodent and human subjects.

Keywords:
Brain imagingBrain mappingHyperpolarizationMagnetic resonance imagingXenon

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Area of Science:

  • Medical Imaging
  • Neuroscience
  • Physics

Background:

  • Traditional MRI detects 1H spins.
  • Hyperpolarized 129-Xenon (HP 129Xe) MRI is an advanced technique.
  • 129Xe can be used for lung imaging due to its gaseous nature.

Purpose of the Study:

  • To develop and detail protocols for imaging the brain using HP 129Xe MRI.
  • To demonstrate the feasibility of HP 129Xe MRI in both rodent and human subjects.
  • To expand the application of HP 129Xe MRI beyond lung imaging.

Main Methods:

  • Development of specific imaging protocols for HP 129Xe.
  • Application of these protocols to rodent models.
  • Application of these protocols to human subjects.

Main Results:

  • Successful imaging of 129Xe within the brain parenchyma and vasculature.
  • Demonstration of detailed visualization of brain structures.
  • Establishment of reproducible protocols for brain imaging.

Conclusions:

  • HP 129Xe MRI is a viable technique for brain imaging.
  • The developed protocols enable visualization of brain vasculature and parenchyma.
  • This technique holds promise for neurological research and diagnostics.