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[Analgesic intolerance in asthmatic children].

A Hussein1

  • 1Kinderkrankenhaus, Norderney.

Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
|March 1, 1988
PubMed
Summary

Analgesics intolerance is rare in children, presenting as severe asthma or chronic urticaria, often triggered by infections. Avoiding these drugs is key to managing this condition.

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Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Dermatology

Background:

  • Analgesics intolerance is uncommon in pediatric populations.
  • It can manifest in children with severe asthma, chronic sinusitis, nasal polyps, or chronic urticaria.
  • Symptoms often appear years after asthma onset and can be triggered by respiratory infections.

Observation:

  • Four asthmatic children with varying clinical presentations of analgesics intolerance were studied.
  • Clinical manifestations included severe mixed asthma, chronic sinusitis, nasal polyps, and chronic urticaria.
  • Reactions to analgesics can include severe bronchial obstruction, urticaria, angioedema, collapse, and rhinitis.

Findings:

  • Diagnosis is based on clear patient history or inhalation challenge with lysin-acetylsalicylate.
  • The primary management strategy is strict avoidance of causative analgesic medications.
  • Analgesics inhibit cyclooxygenase, potentially leading to altered prostaglandin and leukotriene metabolism, causing airway obstruction.

Implications:

  • Highlights the importance of considering analgesics intolerance in asthmatic children with specific comorbidities.
  • Emphasizes the need for careful medication review and patient education in managing pediatric asthma.
  • Suggests a mechanism involving prostaglandin and leukotriene pathways in the pathogenesis of analgesic-induced respiratory distress.

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