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Updated: Feb 11, 2026

Calcium Carbonate Formation in the Presence of Biopolymeric Additives
Published on: May 14, 2019
Calcium(ii)-catalyzed enantioselective conjugate additions of amines
Brice E Uno1, Rachel D Dicken1, Louis R Redfern1
1Department of Chemistry , Center for Molecular Innovation and Drug Discovery , Northwestern University , 2145 Sheridan Rd , Evanston , IL 60208 , USA .
Abstract:
The direct enantioselective chiral calcium(ii)·phosphate complex (Ca[CPA]2)-catalyzed conjugate addition of unprotected alkyl amines to maleimides was developed. This mild catalytic system represents a significant advance towards the general convergent asymmetric amination of α,β-unsaturated electrophiles, providing medicinally relevant chiral aminosuccinimide products in high yields and enantioselectivities. Furthermore, the catalyst can be reused directly from a previously chromatographed reaction and still maintain both high yield and selectivity.
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