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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

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Published on: November 24, 2021

Extended depth of focus for coherence-based cellular imaging.

Biwei Yin¹, Chulho Hyun¹, Joseph A Gardecki¹

¹Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA.

|April 21, 2018

Summary

This summary is machine-generated.

Researchers developed a new fiber optics system for optical coherence tomography (OCT) to improve imaging depth. This technology extends the depth of focus (DOF) for clearer visualization of biological tissues.

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High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

Published on: January 11, 2011

Area of Science:

Biomedical Optics
Optical Engineering
Medical Imaging

Background:

Lateral resolution in cross-sectional optical coherence tomography (OCT) is limited by light beam divergence after focusing.
Achieving high resolution over an extended depth range is a significant challenge in OCT imaging.

Purpose of the Study:

To introduce a novel fiber optics system for generating a coaxially focused multimode (CAFM) beam.
To extend the depth of focus (DOF) for improved OCT imaging.
To demonstrate the utility of this technique for high-resolution cross-sectional imaging of biological tissues.

Main Methods:

Fabrication of a specialized fiber optics probe.
Generation of a coaxially focused multimode (CAFM) beam.
Characterization of the extended depth of focus (DOF) compared to conventional Gaussian beams.

Main Results:

The CAFM beam OCT probe achieved a depth of focus (DOF) more than fivefold greater than conventional Gaussian beams.
Enabled cross-sectional imaging of biological tissues with resolved cellular and subcellular structures over a 400 μm depth range.
Demonstrated a compact and straightforward system design.

Conclusions:

The developed CAFM beam OCT technique significantly extends the DOF, overcoming limitations of conventional OCT.
This method provides high-resolution, extended DOF imaging suitable for biological tissue analysis.
The technique shows strong potential for in vivo endoscopic imaging of internal organs.