Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Imaging Studies I: CT and MRI

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...

Radiological Investigation II: MRI and Ventilation Perfusion Scan

Radiological Investigation II: MRI and Ventilation Perfusion Scan

Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...

Self-Evaluation: Self-Enhancement and Self-Verification

Self-Evaluation: Self-Enhancement and Self-Verification

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cerebellar volume alterations are associated with cognitive dysfunction and fatigue in patients with systemic lupus erythematosus.

BMC rheumatology·2026

Same author

Real-time 3-T MRI of peroneal tendon motion during active ankle movement: feasibility and image quality.

European radiology experimental·2026

Same author

Dysregulation of glycogen metabolism in cardiomyopathy caused by glycogenin-1 (GYG1) missense variants.

The Journal of clinical endocrinology and metabolism·2026

Same author

Overexpression of key complement regulators in glioblastoma.

PloS one·2026

Same author

Swedish national recommendations for MR safety 2026.

Insights into imaging·2026

Same author

Effect of app-based mindfulness on extinction recall - a 7T-fMRI study.

Scientific reports·2026

Search research articles

Related Experiment Video

Updated: Feb 11, 2026

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

Brain Tumor Characterization Using Multibiometric Evaluation of MRI.

Faris Durmo¹, Jimmy Lätt², Anna Rydelius³

¹Department of Radiology, Clinical Sciences Lund, Lund University, Lund, Sweden.

Tomography (Ann Arbor, Mich.)

|April 21, 2018

Summary

This summary is machine-generated.

This study shows that combining MRI volume, perfusion, and diffusion metrics accurately differentiates brain tumors like high-grade gliomas (HGG), low-grade gliomas (LGG), and metastases (MET) before surgery.

Keywords:

MRI brain metastasis brain tumor diffusion-weighted imaging glioma perfusion-weighted imaging sensitivity specificity

More Related Videos

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Related Experiment Videos

Last Updated: Feb 11, 2026

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Area of Science:

Neuroimaging
Oncology
Radiology

Background:

Accurate presurgical differentiation of intracranial tumors is crucial for treatment planning.
High-grade gliomas (HGG), low-grade gliomas (LGG), and metastases (MET) present diagnostic challenges.
Magnetic resonance imaging (MRI) offers various metrics for tumor characterization.

Purpose of the Study:

To evaluate the efficacy of volume, diffusion, and perfusion MRI metrics in distinguishing between HGG, LGG, and MET.
To assess the diagnostic performance of individual and combined MRI parameters.

Main Methods:

Retrospective analysis of preoperative MRI data from 43 patients with pathologically confirmed brain tumors (18 HGG, 10 LGG, 15 MET).
Quantification of MRI biometrics including apparent diffusion coefficient (ADC), cerebral blood flow (CBF), and cerebral blood volume (CBV) using manual region of interest delineation.
Application of binary logistic regression and receiver operating characteristic (ROC) analysis for multiparametric evaluation.

Main Results:

Combined metrics achieved 100% sensitivity and specificity in distinguishing HGG from LGG.
Normalized ADC in edema (nADC-E) differentiated HGG from MET with 68.8% sensitivity and 80% specificity.
A combination of metrics, including edema volume (Vol-E) and normalized ADC, differentiated LGG from MET with 93.3% sensitivity and 100% specificity.

Conclusions:

A multibiometric MRI approach integrating volume, perfusion, and diffusion metrics is effective for preoperative brain tumor diagnosis.
These findings support the clinical utility of advanced MRI techniques for differential diagnosis, warranting further validation and standardization.