Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inertia Tensor01:24

Inertia Tensor

1.2K
The concept of the inertia tensor is employed to depict the mass distribution and rotational inertia of a solid or rigid object. This tensor is expressed through a three-by-three matrix. Each component within this matrix corresponds to varying moments of inertia about specific axes.
The diagonal components of the inertia tensor matrix represent the moments of inertia concerning the principal axes of the object. These primary axes are defined as the axes where the object experiences the least...
1.2K
Diffusion01:12

Diffusion

221.8K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
221.8K
Diffusion01:21

Diffusion

6.5K
Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
6.5K
Brain Imaging01:14

Brain Imaging

760
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
760
Facilitated Diffusion01:16

Facilitated Diffusion

1.3K
The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
1.3K
Multiple Allele Traits01:49

Multiple Allele Traits

38.2K
The Concept of Multiple Allelism
38.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High Definition Magnetic Resonance Imaging of Nasal Tip Ligaments Illustrates Rationale for Ligamentous Preservation.

Plastic and reconstructive surgery·2026
Same author

Magnetic resonance microscopy maps widespread effects of Alzheimer's disease on brain structures and behavior in mice.

Nature neuroscience·2026
Same author

High-resolution MRI Guided Whole Mouse Brain Cell Type Atlas using Deep Learning.

bioRxiv : the preprint server for biology·2025
Same author

Photon-Counting Micro-CT for Bone Morphometry in Murine Models.

Tomography (Ann Arbor, Mich.)·2025
Same author

Directed connectomes across species reveal conserved and divergent pathways of neural signaling.

bioRxiv : the preprint server for biology·2025
Same author

A hierarchical framework for cortical and subcortical gray-matter parcellation across rodents, primates, and humans.

bioRxiv : the preprint server for biology·2025
Same journal

Liver Diffusion Weighted MRI: Effect of Iron Overload on Apparent Diffusion Coefficient.

NMR in biomedicine·2026
Same journal

In Vivo Assessment of Placental Structure and Perfusion in Late-Gestation Pregnancies and Their Association With Fetal Growth.

NMR in biomedicine·2026
Same journal

Reproducibility of Splanchnic Blood Flow Measured Using Phase-Contrast MRI.

NMR in biomedicine·2026
Same journal

Restriction-Weighted Q-Space Trajectory Imaging (ResQ): Toward Mapping Diffusion-Time Effects With Tensor-Valued Diffusion Encoding in Human Prostate Cancer Xenografts.

NMR in biomedicine·2026
Same journal

In Vivo Quantitative Detection of PEGylated Macromolecules by Magnetic Resonance Spectroscopy.

NMR in biomedicine·2026
Same journal

Metabolic Assessment in Human Pluripotent Stem Cell-Derived Cerebral Organoids Using HR-MAS NMR Spectroscopy.

NMR in biomedicine·2026
See all related articles

Related Experiment Video

Updated: Feb 11, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

25.9K

Diffusion tensor imaging using multiple coils for mouse brain connectomics.

John C Nouls1,2, Alexandra Badea1,2, Robert B J Anderson1,2

  • 1Center for In Vivo Microscopy, Radiology, Duke University Medical Center, Durham, NC, USA.

NMR in Biomedicine
|April 21, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel two-coil system to double the speed of mouse brain imaging for connectomics studies. This advancement aids in understanding brain connectivity in neurological and psychiatric diseases.

Keywords:
DTIcoilconnectivity matrixconnectomicsmouse brainthroughput

More Related Videos

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

29.3K
Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
07:00

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Published on: May 7, 2019

9.4K

Related Experiment Videos

Last Updated: Feb 11, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

25.9K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

29.3K
Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
07:00

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Published on: May 7, 2019

9.4K

Area of Science:

  • Neuroimaging
  • Biomedical Engineering

Background:

  • Brain connectivity mapping is crucial for studying neurological and psychiatric diseases using mouse models.
  • Diffusion tensor imaging (DTI) allows non-destructive 3D visualization of neural architecture, enabling tractography, connectivity matrix construction, and connectomics.
  • Current experimental throughput for DTI on mouse models is limited by long acquisition times.

Purpose of the Study:

  • To enhance the throughput of diffusion tensor imaging for mouse brain connectomics.
  • To present a novel two-coil system for preclinical 7-T scanners.
  • To investigate the impact of coil placement and shielding on image quality and data integrity.

Main Methods:

  • Developed and implemented a novel two-coil system with shielded, off-isocenter coils for a 7-T preclinical scanner.
  • Quantified signal-to-noise ratio (SNR) performance and shielding effects in the coil-dominated noise regime.
  • Assessed the impact of gradient field distortions on DTI metrics (fractional anisotropy, eigenvector direction) and connectivity matrix measurements at varying off-isocenter distances.
  • Performed simultaneous imaging on two mouse brain specimens to evaluate throughput and image quality.

Main Results:

  • The novel two-coil system, with shielded coils placed 12 mm off-isocenter, demonstrated no SNR degradation.
  • Gradient field distortions minimally altered connectivity matrix measurements when coils were positioned 12 mm from the isocenter.
  • Simultaneous imaging achieved a practical doubling of DTI throughput for mouse brain specimens.
  • Acquired images were free from shading and artifacts.

Conclusions:

  • The developed two-coil system significantly increases DTI throughput for mouse brain connectomics without compromising image quality or data integrity.
  • This advancement facilitates faster and more efficient research into brain connectivity and its relation to diseases.
  • Future expansion to a four-coil system is proposed to further enhance throughput, with further studies recommended to optimize trade-offs between throughput and matrix integrity.