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Updated: Feb 11, 2026
Acute Myocardial Infarction in Rats
Published on: February 16, 2011
Hemorheologic Alterations in Patients with Type 2 Diabetes Mellitus Presented with an Acute Myocardial Infarction
Kyu Hwan Park1,2, Ung Kim3, Kang Un Choi2
1Department of Internal Medicine, Daegu Veterans Hospital, Daegu, Korea.
Insights
Patients with type 2 diabetes mellitus and acute myocardial infarction show altered blood flow properties, including lower red blood cell elongation index and higher critical shear stress. These hemorheologic changes may aid in managing diabetic patients with heart conditions.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Biophysics
Background:
- Hemorheologic indices are linked to vascular complications.
- Associations between hemorheologic parameters and acute myocardial infarction (AMI) in type 2 diabetes mellitus (T2DM) are not well understood.
- Red blood cell deformability and blood viscosity are key hemorheologic factors.
Purpose of the Study:
- To investigate hemorheologic changes in patients with T2DM with and without AMI.
- To specifically compare the elongation index (EI) and critical shear stress (CSS) between these groups.
Main Methods:
- 195 patients with T2DM were enrolled and divided into an AMI group (n=77) and a control group without coronary artery disease (n=118).
- Hemorheologic parameters, EI and CSS, were measured.
- Statistical comparisons were made between the AMI+ and AMI- groups.
Main Results:
- Patients with AMI exhibited a significantly lower EI (30.44%±1.77%) compared to controls (31.47%±1.48%).
- Patients with AMI showed a significantly higher CSS (316.13±108.20 mPa) than controls (286.80±85.34 mPa).
- CSS correlated with erythrocyte sedimentation rate and dipeptidyl peptidase-4 inhibitor use.
Conclusions:
- Type 2 diabetes mellitus patients with AMI experience adverse hemorheologic alterations, characterized by reduced EI and elevated CSS.
- Hemorheologic parameter assessment offers valuable supplementary data for managing AMI in T2DM patients.
Background:
Hemorheologic indices are known to be related to vascular complications in variable clinical settings. However, little is known about the associations between hemorheologic parameters and acute myocardial infarction (AMI) in type 2 diabetes mellitus (T2DM). The purpose of this study was to demonstrate the changes of hemorheologic environment inside of blood using hemorheologic parameters, especially the elongation index (EI) and critical shear stress (CSS) in diabetics with versus without AMI.
Methods:
A total of 195 patients with T2DM were enrolled. Patients were divided into the study group with AMI (AMI+, n=77) and control group (AMI-, n=118) who had no history of coronary artery disease. Hemorheologic parameters such as EI and CSS were measured and compared between the two groups.
Results:
The EI was lower (30.44%±1.77% in AMI+ and 31.47%±1.48% in AMI-, P<0.001) but the level of CSS was higher (316.13±108.20 mPa in AMI+ and 286.80±85.34 mPa in AMI-, P=0.040) in the AMI+. The CSS was significantly related to the erythrocyte sedimentation rate (R²=0.497, P<0.001) and use of dipeptidyl peptidase-4 inhibitors (R²=0.574, P=0.048).
Conclusion:
Diabetics with AMI resulted in adverse hemorheologic changes with lower EI and higher CSS compared to diabetic subjects without AMI. Evaluation of the hemorheologic parameters may provide valuable supplementary information for managing patients with AMI and T2DM.
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