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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
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[Deep brain stimulation for psychiatric disorders].

M Figee1, P R Schuurman, D Denys

  • 1Academisch Medisch Centrum, Amsterdam.

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|April 21, 2018
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Summary
This summary is machine-generated.

Deep brain stimulation (DBS) uses implanted electrodes to correct abnormal brain activity. This safe and effective treatment is approved for obsessive-compulsive disorder and may help with depression, with potential for other psychiatric conditions.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neurosurgery

Background:

  • Deep brain stimulation (DBS) modulates aberrant neural network activity using high-frequency electrical currents delivered via implanted brain electrodes.
  • DBS has demonstrated efficacy and safety in treating therapy-refractory obsessive-compulsive disorder (OCD).

Purpose of the Study:

  • To review the current applications and future potential of DBS in psychiatric disorders.
  • To explore the neurobiological underpinnings of DBS's therapeutic effects on brain networks.

Main Methods:

  • Review of existing literature on DBS for psychiatric conditions.
  • Analysis of the mechanisms by which DBS influences relevant brain networks.

Main Results:

  • DBS is an effective and safe treatment for therapy-refractory OCD.
  • DBS shows potential for treating therapy-refractory major depressive disorder.
  • Investigational uses of DBS include Tourette syndrome, addiction, anorexia nervosa, PTSD, autism, and schizophrenia.

Conclusions:

  • DBS effectively targets and corrects pathological brain network activity in psychiatric disorders.
  • The broad influence of DBS on neural networks suggests potential for wider application in psychiatry.
  • Further research may expand DBS indications for various complex neuropsychiatric conditions.