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Characterization of SCCmec type IV methicillin-resistant Staphylococcus aureus clones increased in Japanese hospitals

Hidemasa Nakaminami1, Shunsuke Takadama1, Ayumu Ito1

  • 1Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.

Journal of Medical Microbiology
|April 21, 2018
PubMed

Insights

Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) with SCCmec type IV are increasing in Japanese hospitals. The CC1-SCCmec type IV clone, originating from the community, is now predominant in hospitals.

Area of Science:

  • Microbiology
  • Epidemiology
  • Infectious Diseases

Background:

  • Staphylococcal cassette chromosome mec (SCCmec) type IV isolates are the primary cause of community-acquired methicillin-resistant Staphylococcus aureus (MRSA).
  • An increasing prevalence of SCCmec type IV MRSA has been observed in Japanese hospitals.

Purpose of the Study:

  • To investigate the molecular epidemiological characteristics of SCCmec type IV clones in Japanese hospitals.
  • To understand the emergence and spread of specific MRSA clones within healthcare settings.

Main Methods:

  • Analysis of 2589 MRSA isolates from four Tokyo hospitals (2010-2014).
  • Utilized multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE).
  • Assessed antimicrobial susceptibility profiles.

Main Results:

  • SCCmec type IV surpassed SCCmec type II as the predominant MRSA type in 2014.
  • CC1 was identified as the most prevalent clone among SCCmec type IV isolates.
  • Clinical and molecular data suggest the CC1-SCCmec type IV (CC1-IV) clone originated in the community.

Conclusions:

  • The CC1-IV clone is emerging as a dominant MRSA clone in Japanese hospitals.
  • This highlights the increasing impact of community-acquired MRSA strains on hospital epidemiology.
  • Further surveillance is needed to monitor the spread of CC1-IV.
Keywords:
clonal complex 1community-acquired methicillin-resistant Staphylococcus aureushospital-acquired methicillin-resistant Staphylococcus aureusstaphylococcal cassette chromosome mec type IV

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