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Related Concept Videos

Immunological Memory01:23

Immunological Memory

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Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
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Cohesion01:07

Cohesion

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Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar molecule. An oxygen atom in one water molecule has a partial negative charge that can bind to a hydrogen atom with a partial positive charge in a second water molecule, forming a hydrogen bond. Each water molecule can form up to four hydrogen bonds with other water molecules. Hydrogen bonds are responsible for water's cohesive nature.
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Conformity01:20

Conformity

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Conformity is the change in a person’s behavior to go along with the group, even if that person does not agree with the group.
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Symbiosis00:58

Symbiosis

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Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
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Group Polarization01:01

Group Polarization

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Group polarization is the strengthening of an original group attitude following the discussion of views within a group (Teger & Pruitt, 1967). That is, if a group initially favors a viewpoint, after discussion the group consensus is likely a stronger endorsement of the viewpoint. Conversely, if the group was initially opposed to a viewpoint, group discussion would likely lead to stronger opposition.
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Antibody Structure01:10

Antibody Structure

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Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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Antibodies consist of four polypeptide chains: two identical heavy...
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Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IgE-class-specific immunosuppression in offspring by administration of anti-IgE to pregnant mice.

The Journal of allergy and clinical immunology·2018
Same author

Pillars Article: Physico-Chemical Properties of Human Reaginic Antibody: IV. Presence of a Unique Immunoglobulin as a Carrier of Reaginic Activity. J. Immunol. 1966. 97: 75-85.

Journal of immunology (Baltimore, Md. : 1950)·2016
Same author

Pillars Article: Physicochemical Properties of Reaginic Antibody: V. Correlation of Reaginic Activity with γE-Globulin Antibody. J. Immunol. 1966. 97: 840-853.

Journal of immunology (Baltimore, Md. : 1950)·2016
Same author

Identification of IgE.

The Journal of allergy and clinical immunology·2016
Same author

Kimishige Ishizaka. Tokyo, Japan.

Chemical immunology and allergy·2014
Same author

Mast cells and IgE: from history to today.

Allergology international : official journal of the Japanese Society of Allergology·2013

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The Way We Walked with Immunology.

Kimishige Ishizaka1

  • 1La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA;

Annual Review of Immunology
|April 21, 2018
PubMed
Summary

The discovery of Immunoglobulin E (IgE) over 50 years ago revolutionized allergy and asthma treatment. This career retrospective highlights key immunoglobulin research and its impact on immunology.

Area of Science:

  • Immunology
  • Allergy Research
  • Biochemistry

Background:

  • The discovery of Immunoglobulin E (IgE) marked a significant milestone in understanding allergic responses.
  • IgE is a crucial target for developing therapies for allergies and severe asthma.

Discussion:

  • This abstract traces a career path from initial interest in immunochemistry to significant contributions in immunoglobulin research.
  • It covers discoveries in the biological and chemical aspects of immunoglobulins.
  • The narrative also includes contributions to the immunology community and leadership roles in academic institutions.

Key Insights:

  • The pivotal role of IgE in allergic diseases.
  • Advancements in the understanding of immunoglobulin biology and chemistry.
Keywords:
IgEJapanallergyimmunoglobulinmast cell

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  • The importance of scientific community engagement and institutional development.

    • Outlook:

    • Continued exploration of IgE's role in immune responses.
    • Development of novel therapeutic strategies targeting IgE.
    • Fostering future research and collaboration in immunology.