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Is etretinate dangerous in Papillon-Lefèvre syndrome?
A Tosti1, P Manuzzi, F Bardazzi
1Department of Dermatology, University of Bologna, Italy.
Dermatologica
|January 1, 1988
Abstract:
A 23-year-old girl affected by Papillon-Lefèvre syndrome developed, during Etretinate therapy (1 mg/kg/day), two liver abscesses caused by pyogenic bacteria and a subphrenic abscess. The immunological effects of retinoids may precipitate severe infections in patients with Papillon-Lefèvre syndrome, who probably have a basic, even though not always evident, defect of PMN chemotaxis.