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In-situ Tapering of Chalcogenide Fiber for Mid-infrared Supercontinuum Generation

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Published on: May 27, 2013

Mid-Infrared Spectroscopy of Pharmaceutical Solids.

Harry G Brittain¹

¹Center for Pharmaceutical Physics, Milford, NJ, United States.

Profiles of Drug Substances, Excipients, and Related Methodology

|April 22, 2018

Summary

Infrared spectroscopy is a powerful tool for analyzing pharmaceutical solids, revealing details about their solid-state properties, polymorphism, hydrates, and cocrystals. This review covers the technique

Keywords:

Acidic drug substances Acids, bases, and salts Attenuated total reflectance Basic drug substances Cocrystal systems FTIR sampling Fourier transform Infrared spectroscopy Molecular vibration Polymorphism Qualitative identification Solvatomorphism Spectroscopy of polyatomic molecules

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Area of Science:

Pharmaceutical Solid-State Characterization
Spectroscopic Techniques
Materials Science

Background:

Infrared absorption spectroscopy is a well-established method for the physical characterization of pharmaceutical solids.
Spectra analysis, particularly energy values, provides insights into solid-state properties.
The technique is valuable for identification, polymorphism studies, hydrate analysis, and cocrystal investigations.

Purpose of the Study:

To provide a comprehensive overview of the theoretical foundations of infrared spectroscopy.
To illustrate the practical applications of infrared spectroscopy in pharmaceutical solid-state analysis.
To highlight the growing importance of FTIR in studying drug substances, hydrates, and cocrystals.

Main Methods:

Review of theoretical principles underlying infrared absorption spectroscopy.
Analysis of spectral data to understand solid-state properties.
Examination of case studies involving drug substances, hydrates, and cocrystals.

Main Results:

Infrared spectroscopy offers a robust method for identifying pharmaceutical solids.
Trends in spectral energy values correlate with solid-state properties.
FTIR is effective for evaluating polymorphism, hydrate water content, and cocrystal systems.

Conclusions:

Infrared spectroscopy is a versatile and powerful technique for pharmaceutical solid-state characterization.
The methodology is essential for understanding polymorphism, hydrates, and cocrystals.
This review provides foundational knowledge and practical examples for applying infrared spectroscopy.