Related Experiment Video
Updated: Feb 11, 2026
09:44
Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
11.1K
Effective Postoperative Analgesia Using Intravenous Flurbiprofen and Acetaminophen
Mitsuhiro Yoshida1, Yoshitaka Shimizu2, Keita Yoshida3
1Lecturer, Section of Dental Anesthesiology, Department of Oral and Maxillofacial Surgery and Oral Medicine, Hiroshima University Hospital, Hiroshima, Japan.
Summary
Acetaminophen offers effective pain relief after dental surgery, comparable to fentanyl when combined with NSAIDs. This makes acetaminophen a safe alternative when narcotic pain relievers are not advised.
Area of Science:
- Anesthesiology
- Pharmacology
- Oral Surgery
Background:
- Postoperative pain management is critical in dental surgery.
- Narcotic analgesics are often used but carry risks and contraindications.
Purpose of the Study:
- To evaluate acetaminophen as an alternative to fentanyl for postoperative pain relief in dental surgery.
- To compare acetaminophen with fentanyl when used in combination with a nonsteroidal anti-inflammatory drug (NSAID).
Main Methods:
- A comparative study involving male patients undergoing mandibular cyst enucleation under general anesthesia.
- Patients received either an NSAID with fentanyl or an NSAID with acetaminophen.
- Key metrics included time to operating room discharge and postoperative pain levels.
Main Results:
- Patients receiving acetaminophen with an NSAID had a significantly shorter time to operating room discharge compared to those receiving fentanyl with an NSAID.
- No significant difference in postoperative analgesic effect was observed between the two groups.
Conclusions:
- Acetaminophen is an equipotent analgesic to fentanyl when combined with an NSAID for dental surgery.
- Acetaminophen serves as a viable alternative to fentanyl, especially when narcotic use is contraindicated.
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