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miR-485-5p suppresses breast cancer progression and chemosensitivity by targeting survivin

Meng Wang1, Wen-Run Cai1, Ran Meng1

  • 1The First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China; Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China; Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, 300060, China.

Biochemical and Biophysical Research Communications
|April 22, 2018
PubMed

Insights

MicroRNA-485-5p (miR-485-5p) suppresses breast cancer progression and enhances chemotherapy sensitivity by targeting survivin. This discovery offers a potential strategy to overcome chemoresistance in breast cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer is a leading global cancer in women.
  • Chemoresistance is a major challenge in breast cancer therapy, often linked to microRNA (miRNA) dysregulation.
  • miR-485-5p is a known tumor suppressor, but its role in breast cancer chemosensitivity was previously unknown.

Purpose of the Study:

  • To investigate the role of miR-485-5p in breast cancer progression and chemosensitivity.
  • To identify the molecular targets of miR-485-5p in breast cancer.

Main Methods:

  • In vitro and in vivo experiments were conducted to assess the effects of miR-485-5p.
  • Bioinformatic analysis and luciferase reporter assays were used to identify miR-485-5p targets.
  • Survivin expression levels were manipulated to study its interaction with miR-485-5p.

Main Results:

  • Overexpression of miR-485-5p suppressed breast cancer progression in vitro and in vivo.
  • miR-485-5p was found to directly target the 3'-untranslated region of survivin.
  • Overexpression of survivin counteracted the effects of miR-485-5p on breast cancer.

Conclusions:

  • miR-485-5p acts as a tumor suppressor in breast cancer.
  • The miR-485-5p/survivin axis plays a critical role in regulating breast cancer progression and chemosensitivity.
  • Targeting survivin with miR-485-5p presents a potential therapeutic strategy to reverse chemoresistance in breast cancer.
Keywords:
Breast cancerChemoresistanceSurvivinmiR-485-5p

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