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L-asparaginase effect on antithrombin-III levels
Medical and Pediatric Oncology
|January 1, 1979
Summary
L-asparaginase therapy significantly lowers antithrombin-III (AT-III) levels in leukemia patients, potentially increasing thrombosis risk. Levels recover slowly after treatment cessation.
Area of Science:
- Hematology
- Oncology
- Biochemistry
Background:
- Acute lymphoblastic leukemia (ALL) treatment often involves L-asparaginase (L-asp).
- L-asp depletes asparagine, impacting protein synthesis.
- Antithrombin-III (AT-III) is a crucial coagulation inhibitor.