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Related Experiment Videos

L-asparaginase effect on antithrombin-III levels.

N Anderson, J J Lokich, J L Tullis

    Medical and Pediatric Oncology
    |January 1, 1979
    PubMed
    Summary

    L-asparaginase therapy significantly lowers antithrombin-III (AT-III) levels in leukemia patients, potentially increasing thrombosis risk. Levels recover slowly after treatment cessation.

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    Area of Science:

    • Hematology
    • Oncology
    • Biochemistry

    Background:

    • Acute lymphoblastic leukemia (ALL) treatment often involves L-asparaginase (L-asp).
    • L-asp depletes asparagine, impacting protein synthesis.
    • Antithrombin-III (AT-III) is a crucial coagulation inhibitor.