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Intracranial Cryptococcoma-Clinicopathologic Correlation and Surgical Outcome: A Single-Institution Experience
Alok Uppar1, A R Prabhu Raj1, Subhas Konar1
1Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India.
World Neurosurgery
|April 22, 2018
Summary
Intracranial cryptococcoma, often caused by Cryptococcus gattii, requires early diagnosis and surgical decompression. Prompt antifungal therapy, including amphotericin B and fluconazole, improves patient outcomes and reduces mortality.
Area of Science:
- Neuroscience
- Infectious Diseases
- Pathology
Background:
- Intracranial cryptococcoma is a rare fungal infection of the brain.
- It can be caused by Cryptococcus gattii and Cryptococcus neoformans.
- Understanding its clinical presentation and outcomes is crucial for effective management.
Purpose of the Study:
- To detail the clinical characteristics of intracranial cryptococcoma.
- To analyze clinicopathologic findings and surgical outcomes.
- To identify factors influencing patient prognosis.
Main Methods:
- A retrospective case series of 5 patients with confirmed intracranial cryptococcoma.
- Clinical data, imaging (CT scans), and pathological findings were reviewed.
- Treatment modalities and patient follow-up data were analyzed.
Main Results:
- Most patients were adults (3rd-5th decades); lesions were supratentorial or in the posterior fossa.
- Common symptoms included fever, papilledema, and meningeal irritation; most patients were immunocompetent.
- Surgical decompression was performed in 4/5 patients, with 80% achieving good outcomes after antifungal therapy.
Conclusions:
- Cryptococcus gattii is an important cause of intracranial cryptococcoma.
- Early diagnosis, surgical decompression, and aggressive antifungal therapy (amphotericin B and fluconazole) are vital.
- Timely intervention can significantly decrease morbidity and mortality.
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