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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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CD44 directed nanomicellar payload delivery platform for selective anticancer effect and tumor specific imaging of

Zhaoxian Wang1, Samaresh Sau1, Hashem O Alsaab1

  • 1Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.

Nanomedicine : Nanotechnology, Biology, and Medicine
|April 22, 2018
PubMed

Insights

Researchers developed a novel nanoparticle for triple-negative breast cancer (TNBC) that targets CD44 receptors. This targeted therapy platform combines imaging and drug delivery for effective TNBC treatment.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Triple-negative breast cancer (TNBC) is aggressive and lacks targeted therapy options.
  • Early detection and effective treatment of TNBC remain critical challenges.
  • CD44 receptor is a promising target for TNBC therapy.

Purpose of the Study:

  • To develop a CD44-targeted nanomicelle (NM) platform for multimodal imaging and therapy of TNBC.
  • To encapsulate a potent curcumin analogue (CDF) within the NM for targeted drug delivery.
  • To evaluate the efficacy of the NM for TNBC cell targeting, apoptosis induction, and in vivo tumor imaging.

Main Methods:

  • Fabrication of Hyaluronic Acid (HA)-decorated Styrene Maleic Anhydride (SMA) and Vitamin E TPGS (HA-SMA-TPGS) oligomers.
  • Self-assembly of HA-SMA-TPGS into nanomicelles encapsulating curcumin analogue (CDF).
  • In vitro evaluation of CD44-mediated targeting and apoptosis induction in TNBC cells.
  • In vivo tumor imaging using a near-infrared (NIR) fluorescent dye (S0456) conjugate.

Main Results:

  • HA-SMA-TPGS-CDF nanomicelles exhibited excellent characteristics for parenteral delivery.
  • Targeted nanomicelles selectively induced apoptosis in CD44-positive TNBC cells.
  • In vivo imaging demonstrated significant TNBC tumor accumulation of HA-SMA-TPGS-S0456 with minimal off-target organ uptake.

Conclusions:

  • The developed HA-SMA-TPGS-CDF nanomicelles represent a promising platform for CD44-mediated targeted therapy of TNBC.
  • This platform enables simultaneous near-infrared fluorescence imaging and cytotoxic drug delivery.
  • This multimodal approach offers a novel strategy for advancing TNBC diagnosis and treatment.
Keywords:
ApoptosisCD44 targetingFluorescence imaging of TNBCNano-micellesTriple negative breast cancerVitamin E-TPGS

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