Related Experiment Video

Updated: Feb 11, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
07:42

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

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Reversible metronidazole-induced neurotoxicity after 10 weeks of therapy

Wafa AlDhaleei1, Ayesha AlMarzooqi1, Nouran Gaber1

  • 1Internal Medicine, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.

BMJ Case Reports
|April 22, 2018
PubMed

Insights

Metronidazole can cause rare central neurotoxicity, presenting as neurological deficits. This reversible side effect is typically diagnosed via neuroimaging during acute neurological changes.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pharmacology

Background:

  • Metronidazole is a widely used antimicrobial agent.
  • Common side effects include gastrointestinal issues and hypersensitivity.
  • Neurotoxicity is a rare but reported adverse effect.

Observation:

  • This case report details metronidazole-induced central neurotoxicity.
  • The patient, a 38-year-old male, received metronidazole for over 10 weeks for a brain abscess.
  • Neurological manifestations ranged from headache to focal deficits.

Findings:

  • Central neurotoxicity from metronidazole is rare but reversible.
  • Diagnosis relies on neuroimaging in patients with acute neurological changes.
  • Peripheral neuropathy (sensory loss) is the most common neurological manifestation.

Implications:

  • Clinicians should consider metronidazole-induced neurotoxicity in patients presenting with neurological symptoms.
  • Prompt diagnosis and discontinuation of metronidazole can lead to reversible neurological recovery.
  • Further research into the mechanisms and risk factors for metronidazole neurotoxicity is warranted.
Keywords:
drugs and medicinesneurology (drugs and medicines)radiology (diagnostics)

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