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Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

393
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
393
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

395
 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
395
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

368
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
368
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

425
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
425
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

458
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
458
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.2K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Updated: Feb 11, 2026

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease
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Interventions for lower extremity peripheral artery disease.

Jade S Hiramoto1, Martin Teraa2, Gert J de Borst2

  • 1Division of Vascular and Endovascular Surgery, University of California, San Francisco, CA, USA.

Nature Reviews. Cardiology
|April 22, 2018
PubMed
Summary
This summary is machine-generated.

Peripheral artery disease (PAD) affects lower limbs due to atherosclerosis, driven by aging and lifestyle factors. Current treatments offer limited limb benefits, highlighting the need for comparative effectiveness research.

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Area of Science:

  • Vascular Medicine
  • Cardiovascular Disease
  • Atherosclerosis Research

Background:

  • Peripheral artery disease (PAD) is a growing global health concern, linked to aging, diabetes, metabolic syndrome, and smoking.
  • PAD management involves diverse healthcare professionals, necessitating broad familiarity with risk factors, diagnosis, and treatments.
  • While medical therapies are crucial for secondary prevention, their direct benefits for advanced PAD limb outcomes are limited.

Purpose of the Study:

  • To review the current landscape of peripheral artery disease interventions.
  • To provide a framework for understanding PAD staging, treatment goals, and outcome predictors.
  • To discuss emerging therapies and persistent unmet needs in PAD treatment.

Main Methods:

  • Systematic review of current peripheral artery disease (PAD) interventions.
  • Analysis of disease staging, treatment objectives, and prognostic factors.
  • Evaluation of evolving therapeutic strategies, including cell-based and gene-based approaches.

Main Results:

  • PAD prevalence and healthcare costs are rising globally, driven by demographic and lifestyle factors.
  • Advanced PAD treatments have evolved, but comparative effectiveness data is lacking.
  • Existing medical therapies offer limited direct benefits for limb salvage in severe PAD.

Conclusions:

  • A comprehensive understanding of PAD management, risk factors, and treatment options is essential for healthcare providers.
  • Further research is needed to establish the comparative effectiveness of various limb revascularization technologies.
  • Emerging therapies and addressing unmet needs are critical for improving outcomes in peripheral artery disease.