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Salidroside Protects Against Advanced Glycation End Products-Induced Vascular Endothelial Dysfunction
Peng Zhang1, Yuanmin Li1, Rong Guo2
1Department of Cardio-Thoracic Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China (mainland).
Summary
Salidroside protects against diabetes-induced vascular endothelial dysfunction by improving blood vessel function and reducing oxidative stress. This Rhodiola compound may be a potential therapeutic agent for managing diabetes complications.
Area of Science:
- Pharmacology
- Cardiovascular Biology
- Endocrinology
Background:
- Salidroside, a key Rhodiola compound, shows cardiovascular benefits.
- Diabetes-induced vascular endothelial dysfunction remains a significant health concern.
- The protective effects of salidroside on diabetic endothelial dysfunction are not well understood.
Purpose of the Study:
- To investigate the protective effects of salidroside on endothelial function in diabetes.
- To explore the underlying molecular mechanisms of salidroside's action.
Main Methods:
- Assessed endothelium-dependent relaxation in rat aortas with and without salidroside.
- Evaluated cell viability, oxidative stress markers, and protein expression in human umbilical vein endothelial cells (HUVECs) in vitro.
- Investigated the role of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase 1 (HO-1) and nuclear factor kappa B (NF-κB) signaling pathways.
Main Results:
- Salidroside significantly improved advanced glycation end product (AGE)-induced endothelial dysfunction.
- Salidroside treatment restored nitric oxide (NO) levels and reduced reactive oxygen species (ROS) in AGE-stimulated HUVECs.
- Nrf2/HO-1 and NF-κB signaling pathways were identified as critical for salidroside's beneficial effects.
Conclusions:
- Salidroside demonstrates protective effects against AGE-induced endothelial dysfunction.
- The mechanism involves the induction of HO-1 and attenuation of phosphorylated NF-κB p65.
- Salidroside holds potential as a therapeutic agent for diabetic vascular complications.
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