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Related Concept Videos

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Related Experiment Video

Updated: Feb 11, 2026

In Silico Clinical Trials for Cardiovascular Disease
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Cardiovascular Disease Progression: A Target for Therapy?

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  • 1Cardiovascular Division, University of Minnesota Medical School, Minneapolis.

The American Journal of Medicine
|April 22, 2018
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Summary

This study highlights the importance of targeting cardiovascular disease progression, not just risk factors. A comprehensive noninvasive assessment revealed a strong link between a Disease Score and future cardiovascular events.

Keywords:
Cardiovascular morbid eventsEarly cardiovascular diseaseNoninvasive testingRisk factors

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Area of Science:

  • Cardiology
  • Preventive Medicine
  • Medical Diagnostics

Background:

  • Clinical research for cardiovascular disease prevention primarily targets risk factors.
  • Disease progression, a precursor to morbid events, is often overlooked as a therapeutic target.

Purpose of the Study:

  • To evaluate the utility of a comprehensive noninvasive cardiovascular assessment in individuals without prior cardiovascular disease.
  • To explore the relationship between a composite Disease Score and the risk of future cardiovascular events.

Main Methods:

  • Conducted a noninvasive cardiovascular evaluation over 1 hour in a single setting.
  • Assessed functional and structural abnormalities in small arteries, large arteries, and the left ventricle.
  • Calculated a Disease Score based on the sum of abnormal test results.

Main Results:

  • Preliminary follow-up data show a significant correlation between the Disease Score and the incidence of future morbid events.
  • The comprehensive assessment provides a detailed view of cardiovascular abnormalities in asymptomatic individuals.

Conclusions:

  • Focusing on slowing cardiovascular disease progression in early stages is crucial for prolonging disease-free life expectancy.
  • Noninvasive assessments can identify individuals at risk and guide therapeutic strategies.