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Peripheral artery disease: a micro-RNA-related condition?

Georgia Vogiatzi1, Evangelos Oikonomou1, Spyridon Deftereos1

  • 11st Department of Cardiology, 'Hippokration' Hospital, University of Athens, Medical School, Athens, Greece.

Current Opinion in Pharmacology
|April 22, 2018
PubMed

Insights

Peripheral artery disease (PAD) involves atherosclerosis. MicroRNAs (miRNAs) show disease-specific expression, offering potential as diagnostic biomarkers and therapeutic targets for PAD patients.

Area of Science:

  • Cardiovascular research
  • Molecular biology
  • Biomarker discovery

Background:

  • Peripheral artery disease (PAD) is a significant cause of cardiovascular morbidity and mortality, characterized by diffuse atherosclerosis.
  • Understanding the molecular mechanisms of PAD is crucial for improving patient outcomes.
  • MicroRNAs (miRNAs), small noncoding RNAs, exhibit disease-specific expression patterns and are stable in circulation.

Purpose of the Study:

  • To review the current literature on the role of specific microRNAs (miRNAs) in the context of peripheral artery disease (PAD).
  • To explore the potential of miRNAs in regulating angiogenesis and vascular integrity in PAD.
  • To highlight the utility of miRNAs as minimally invasive diagnostic biomarkers and for risk stratification in PAD.

Main Methods:

  • Literature review of studies investigating microRNA regulation in peripheral artery disease.
  • Analysis of research focusing on miRNA roles in angiogenesis and vascular maintenance.
  • Synthesis of findings related to miRNA expression in PAD for diagnostic and prognostic potential.

Main Results:

  • Specific microRNAs (miRNAs) are implicated in the molecular pathology of peripheral artery disease (PAD).
  • miRNA dysregulation affects key processes such as angiogenesis and vascular integrity in PAD.
  • Circulating miRNAs present a promising avenue for minimally invasive diagnosis and risk stratification in PAD.

Conclusions:

  • MicroRNAs (miRNAs) are emerging as critical regulators in peripheral artery disease (PAD) pathogenesis.
  • miRNAs hold significant potential as novel, minimally invasive biomarkers for PAD diagnosis and risk assessment.
  • Further research into miRNA-based diagnostics and therapeutics could personalize PAD treatment strategies.

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