Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age-related changes in the skeletal muscle cells.

E Beregi1, O Regius, T Hüttl

  • 1Gerontology Center, Semmelweis Medical University, Budapest, Hungary.

Zeitschrift Fur Gerontologie
|March 1, 1988
PubMed
Summary

Aging causes significant changes in skeletal muscle mitochondria, leading to disruptions and the accumulation of lipofuscin. These age-related mitochondrial alterations are more pronounced in muscle cells than in lymphocytes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Coronary artery bypass grafting without extracorporeal circulation].

Magyar sebeszet·2002
Same author

[Experience with surgical treatment of prosthetic valve endocarditis].

Orvosi hetilap·2001
Same author

[Esophageal replacement by interposition of pedicled ascending colon flap supplied by the inferior mesenteric artery].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2000
Same author

Venous myogenic tone and its regulation through K+ channels depends on chronic intravascular pressure.

Circulation research·1997
Same author

[Total proximal reconstruction of chronic aortic dissection in patients with Marfan syndrome].

Orvosi hetilap·1997
Same author

[Non-invasive and invasive assessment of the function of aortic valve homografts in infancy and childhood].

Orvosi hetilap·1995

Area of Science:

  • Cell Biology
  • Gerontology
  • Muscle Physiology

Background:

  • Mitochondria are crucial for cellular energy production and function.
  • Aging is associated with cellular damage and functional decline.
  • Previous research indicated age-related mitochondrial changes in lymphocytes.

Purpose of the Study:

  • To investigate age-related changes in skeletal muscle mitochondria.
  • To compare mitochondrial alterations in skeletal muscle with those in lymphocytes.

Main Methods:

  • Electron microscopy was used to examine skeletal muscle cells.
  • Samples were obtained from young and old humans and mice (CBA/Ca strain).

Main Results:

  • Old skeletal muscle mitochondria exhibited age-related changes, including disrupted cristae and myelin-like structures.
  • Giant mitochondria and lipofuscin accumulation were observed in myofibrils, often near damaged mitochondria.
  • Mitochondrial changes were more frequent in skeletal muscle cells compared to lymphocytes.

Conclusions:

  • Skeletal muscle mitochondria undergo significant age-related structural damage.
  • Lipofuscin accumulation is associated with mitochondrial damage in aging muscle.
  • Skeletal muscle cells are more susceptible to age-related mitochondrial alterations than lymphocytes.

Related Experiment Videos