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Published on: February 6, 2017
A Novel Regulator of Type II Diabetes: MicroRNA-143
Biao Li1, Jingjing Fan2, Ning Chen3
1Graduate School, Wuhan Sports University, Wuhan 430079, China; These authors contributed equally to this work.
Abstract:
MiR-143 is an miRNA with the function of specifically inhibiting the insulin-AKT pathway via the downregulation of oxysterol-binding protein-related protein 8 (ORP8), thus resulting in the inhibition of AKT phosphorylation, insulin tolerance, and final development of type II diabetes mellitus (T2DM). Aerobic exercise can prevent T2DM by downregulating miR-143. However, the underlying mechanisms for exercise-induced change of miR-143 remain unclear. In the present study, we will summarize the involvement of miR-143 in regulating the development of T2DM and the underlying mechanisms for potential diagnosis, prevention, and treatments, including exercise intervention for T2DM by targeting miR-143.
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