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Related Experiment Videos

Systemic immunosuppression induced by peritoneal photodynamic therapy.

C J Jolles1, M J Ott, R C Straight

  • 1Division of Gynecologic Oncology, University of Utah School of Medicine, Salt Lake City.

American Journal of Obstetrics and Gynecology
|June 1, 1988
PubMed
Summary

Photodynamic therapy (PDT) can suppress the immune system, particularly when administered peritoneally. This immunosuppression is systemic, linked to an acute-phase response, and may have implications for cancer treatment.

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Area of Science:

  • Immunology
  • Oncology
  • Photochemistry

Background:

  • Photodynamic therapy (PDT) is increasingly used for cancer diagnosis and treatment.
  • The impact of PDT on immune responses remains under-investigated.
  • Understanding PDT's immunomodulatory effects is crucial for optimizing cancer therapy.

Purpose of the Study:

  • To investigate the effects of photodynamic therapy on immune responses in a murine model.
  • To determine if PDT-induced immunosuppression is local or systemic.
  • To explore the relationship between PDT, acute-phase response, and immune function.

Main Methods:

  • Murine model used to assess contact hypersensitivity (CHS) responsiveness after photodynamic therapy (PDT).
  • Comparison of peritoneal PDT versus cutaneous PDT effects.

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  • Adoptive transfer experiments to identify immunosuppressive cells.
  • Monitoring of acute-phase response markers (leukocytosis, serum amyloid P).

    • Main Results:

    • Peritoneal PDT markedly decreased contact hypersensitivity responsiveness, unlike cutaneous PDT.
    • Immunosuppression was systemic, affecting unirradiated sites.
    • Adoptively transferable cells from PDT-treated mice inhibited CHS responses.
    • PDT induced an acute-phase response, including leukocytosis and elevated serum amyloid P.
    • Immunosuppression was reversible but persisted for 3 weeks.

    Conclusions:

    • Photodynamic therapy, especially when delivered peritoneally, can induce significant systemic immunosuppression.
    • A link exists between the acute-phase response and PDT-induced immunosuppression.
    • The potential for detrimental consequences due to decreased immunoresponsiveness warrants consideration in cancer treatment strategies involving PDT.