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Tree nut allergens.

Sabine Geiselhart1, Karin Hoffmann-Sommergruber1, Merima Bublin1

  • 1Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.

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|April 23, 2018
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Summary
This summary is machine-generated.

Tree nut allergy affects up to 4.9% globally, posing serious health risks. This review details known tree nut allergens, their characteristics, and clinical significance for better diagnosis and management.

Keywords:
AllergyComponent resolved diagnosisPrevalenceRecombinant allergensTree nuts

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Area of Science:

  • Food science
  • Immunology
  • Allergology

Background:

  • Tree nuts are nutritious but also significant sources of allergens.
  • Tree nut allergy, mediated by IgE, can cause severe, life-threatening reactions.
  • Global prevalence of tree nut allergy is reported up to 4.9%.

Purpose of the Study:

  • To review current knowledge on tree nut allergens.
  • To describe physicochemical and immunological characterization of these allergens.
  • To discuss the clinical relevance of tree nut allergens.

Main Methods:

  • Literature review of scientific articles on tree nut allergens.
  • Summary of identified allergens for various tree nuts.
  • Analysis of physicochemical and immunological data.
  • Evaluation of clinical relevance and diagnostic applications.

Main Results:

  • Several allergens identified for hazelnut and walnut, with some used in component-resolved diagnosis.
  • Limited allergen identification for macadamia, coconut, and Brazil nuts, with missing data on additional proteins.
  • Physicochemical and immunological properties of known allergens are summarized.
  • Clinical relevance and diagnostic utility are discussed for various tree nuts.

Conclusions:

  • Comprehensive understanding of tree nut allergens is crucial for diagnosis and management.
  • Further research is needed to identify allergens in less-studied tree nuts like macadamia, coconut, and Brazil nut.
  • Component-resolved diagnosis approaches are advancing for some tree nuts, improving allergy management.