Upsetting the Balance: When Viruses Manipulate Cell Polarity Control
Miranda Thomas1, Lawrence Banks1
1ICGEB, Padriciano 99, 34149 Trieste, Italy.
Journal of Molecular Biology
|April 23, 2018
Summary
Viruses frequently target cell polarity control, disrupting host cell functions like immunity and replication. This highlights the critical link between cell polarity and vital cellular processes.
Area of Science:
- Cell Biology
- Virology
- Molecular Biology
Background:
- Cell polarity is crucial for normal cellular function.
- Viruses often exploit host cell machinery for their replication.
- Disruption of cell polarity is a common viral strategy.
Purpose of the Study:
- To examine how viruses interact with and manipulate cell polarity controls.
- To understand the impact of viral interference with cell polarity on host cell processes.
- To elucidate the link between cell polarity and viral life cycles and cell transformation.
Main Methods:
- Analysis of virus-host protein interactions.
- Investigation of viral effects on host cell polarity.
- Study of viral life cycles and virally-induced cell transformation.
Main Results:
- Viruses frequently target key cell polarity control proteins.
- Viral targeting of polarity proteins affects host cell polarity.
- This disruption influences transcription, replication, and immunity.
Conclusions:
- Viruses extensively utilize cell polarity control mechanisms.
- Interference with cell polarity impacts numerous host cell functions.
- Cellular processes are intimately linked to cell polarity control.
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