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The expression profile of PD-L1 and CD8+ lymphocyte in pituitary adenomas indicating for immunotherapy

Peng-Fei Wang1, Ting-Jian Wang1, Ya-Kun Yang1

  • 1Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.

Journal of Neuro-Oncology
|April 23, 2018
PubMed
Abstract

Insights

Programmed death-ligand 1 (PD-L1) and CD8+ tumor-infiltrating lymphocytes (TILs) were investigated in pituitary adenomas (PAs). PD-L1 was frequently expressed in functioning PAs, suggesting immunotherapy potential for PAs.

Area of Science:

  • Neuro-oncology
  • Immunology
  • Endocrinology

Background:

  • Pituitary adenomas (PAs) are common brain tumors, with some subtypes resistant to standard treatments.
  • Novel therapeutic strategies are needed for treatment-refractory PAs.
  • Programmed death 1 (PD-1) blockade shows promise in various cancers, with PD-L1 and CD8+ tumor-infiltrating lymphocyte (TILs) as predictive markers.

Purpose of the Study:

  • To investigate the expression of PD-L1 and CD8+ TILs in PAs.
  • To evaluate the potential of immunotherapy for pituitary adenomas.

Main Methods:

  • Immunohistochemistry (IHC) was used to detect PD-L1 and CD8+ TIL expression in 191 PAs.
  • Statistical analyses (chi-squared tests, Fisher's exact test) compared marker expression across PA subtypes and clinical parameters.

Main Results:

  • PD-L1 was positive in 36.6% and CD8+ TILs in 86.9% of PAs.
  • PD-L1 expression was significantly higher in functioning PAs (58.8%) versus non-functioning PAs (34.3%).
  • PD-L1 expression correlated with PRL, GH, ACTH, cortisol levels, PRL/GH immunostaining, and higher Ki-67 index; CD8+ TILs correlated with GH levels and PRL immunostaining.

Conclusions:

  • PD-L1 is frequently expressed in functioning PAs and associated with aggressive features.
  • These findings suggest that PD-1 blockade immunotherapy could be a viable treatment option for PAs.
Keywords:
CD8+ lymphocyteImmunotherapyPD-L1Pituitary adenomas

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