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Risk factors for metastasis at presentation with conventional chondrosarcoma: a population-based study
Kehan Song1, Xiao Shi2, Xin Liang3
1Department of Orthopaedics, Huashan Hospital, Fudan University, No.12 Wulumuqizhong Road, Shanghai, 200040, China.
International Orthopaedics
|April 23, 2018
Summary
Older age, axial or craniofacial tumor location, higher grade, and larger tumor size increase metastasis risk in conventional chondrosarcoma patients at diagnosis.
Area of Science:
- Oncology
- Orthopedic Oncology
- Cancer Research
Background:
- Conventional chondrosarcoma is a rare bone malignancy.
- Metastasis at diagnosis significantly impacts patient prognosis and treatment strategies.
Purpose of the Study:
- To identify risk factors associated with metastasis at the time of diagnosis for conventional chondrosarcoma.
- To inform early detection and risk stratification for patients with this rare cancer.
Main Methods:
- Utilized data from the Surveillance, Epidemiology, and End Results (SEER) database (1983-2014).
- Included 2,349 patients diagnosed with conventional chondrosarcoma.
- Employed univariate and multivariate logistic regression analyses to identify risk factors.
Main Results:
- Older age (≥60 years), axial or craniofacial tumor location, higher tumor grade (II or III), and larger tumor size (>10 cm) were significantly associated with increased risk of metastasis.
- Specific odds ratios (OR) and confidence intervals (CI) were calculated for each risk factor.
Conclusions:
- Conventional chondrosarcoma patients presenting with older age, axial/craniofacial location, higher grade, or larger tumor size face a greater likelihood of metastasis at diagnosis.
- These factors are critical for assessing metastatic potential and guiding clinical management.
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