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Updated: Feb 11, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common
Wensheng Yu, Ling Tong, Oleg Selyutin
1WuXi AppTec , 288 Fute Zhong Road , Shanghai 200131 , China.
Abstract:
We describe the discovery of MK-6169, a potent and pan-genotype hepatitis C virus NS5A inhibitor with optimized activity against common resistance-associated substitutions. SAR studies around the combination of changes to both the valine and aminal carbon region of elbasvir led to the discovery of a series of compounds with substantially improved potency against common resistance-associated substitutions in the major genotypes, as well as good pharmacokinetics in both rat and dog. Through further optimization of key leads from this effort, MK-6169 (21) was discovered as a preclinical candidate for further development.
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