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Method to Measure Tone of Axial and Proximal Muscle
Published on: December 14, 2011
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Biologics for treating axial spondyloarthritis
Alexis Jones1, Coziana Ciurtin2, Mediola Ismajli3
1a Rheumatology Department , University College London Hospitals, NHS Foundation Trust , London , United Kingdom of Great Britain and Northern Ireland.
Expert Opinion on Biological Therapy
|April 24, 2018
Summary
Advances in axial spondyloarthritis (axSpA) treatment include anti-tumour necrosis factor (TNF) therapies, IL-17 inhibition, and Janus kinase (JAK) inhibitors. Biosimilars enhance treatment accessibility and choice for patients.
Area of Science:
- Rheumatology
- Immunology
- Genetics
Background:
- Spondyloarthritis (SpA) is a group of diseases with shared features.
- Axial spondyloarthritis (axSpA) involves axial skeleton inflammation, causing chronic back pain and sacroiliitis.
- Human leukocyte antigen (HLA) B27 is strongly associated with axSpA.
Purpose of the Study:
- To review current biologic therapies for axSpA.
- To discuss the emergence and impact of biosimilars.
- To explore future therapeutic targets and agents for axSpA.
Main Methods:
- Review of current literature on axSpA treatments.
- Analysis of advancements in biologic therapies.
- Evaluation of biosimilars and emerging drug classes.
Main Results:
- Anti-tumour necrosis factor (TNF) therapies have significantly improved axSpA treatment.
- Interleukin-17 (IL-17) inhibition presents an alternative therapeutic target.
- Janus kinase (JAK) inhibitors and IL-17/IL-23 pathway inhibition show promise.
Conclusions:
- Significant progress has been made in axSpA treatment, with biologics revolutionizing patient care.
- Biosimilars increase affordability and patient choice in axSpA therapeutics.
- Targeting IL-17/IL-23 pathways and using JAK inhibitors represent promising future directions.
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