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Updated: Feb 11, 2026

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
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A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

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An Outbreak of Penicillin-Resistant Streptococcus Pneumoniae Infections on an Internal Medicine Ward

Ichiro Tatara1, Kenji Kono1, Seiji Takeda1

  • 1The Second Department of Internal Medicine, Fukuoka University, School of Medicine, Fukuoka, Japan.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|April 24, 2018
PubMed

Insights

Penicillin-resistant Streptococcus pneumoniae (PRSP) caused hospital infections in 1993. While most patients recovered with antibiotics, vigilance is crucial due to treatment challenges.

Area of Science:

  • Medicine
  • Infectious Diseases
  • Hospital Epidemiology

Background:

  • An outbreak of penicillin-resistant Streptococcus pneumoniae (PRSP) occurred in a hospital ward.
  • Nine patients were identified with infections or colonization.

Purpose of the Study:

  • To report on the characteristics and outcomes of a PRSP outbreak.
  • To highlight the emergence of antibiotic-resistant bacteria in a hospital setting.

Main Methods:

  • Retrospective review of patient cases during the outbreak period.
  • Identification of bacterial strains and modes of transmission.
  • Analysis of treatment regimens and patient outcomes.

Main Results:

  • The outbreak involved pneumonia, acute bronchitis, and respiratory colonization.
  • Most cases were nosocomial, with evidence of at least two strains.
  • Pneumonia cases were likely droplet-transmitted cross-infections.
  • All infected patients were successfully treated with antibiotics like imipenem and ofloxacin.

Conclusions:

  • PRSP infections pose treatment challenges.
  • Continuous monitoring for antibiotic-resistant pathogens is essential in healthcare settings.
  • Prompt and appropriate antibiotic therapy can lead to successful patient outcomes.
Keywords:
droplet transmissionnosocomial infectionpenicillin-resistant Streptococcus pneumoniae

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