Related Experiment Video
Updated: Feb 11, 2026

Analysis of Oxidative Stress in Zebrafish Embryos
Published on: July 7, 2014
Sex Matters: Interfering with the Oxidative Stress Response in Pachyonychia Congenita
Rudolf E Leube1, Nicole Schwarz1
1Institute of Molecular and Cellular Anatomy, Rheinisch-Westfälische Technische Hochschule Aachen University, Aachen, Germany.
Abstract:
Pachyonychia congenita is an incurable and often debilitating genodermatosis. Topical application of the antioxidative response inducer sulforaphane, however, alleviates disease symptoms in a murine pachyonychia congenita model, forecasting clinical benefits. The Coulombe laboratory now reports sex-dependent differences in sulforaphane responsiveness of pachyonychia congenita mice, thereby dampening treatment expectations but also unveiling novel aspects of sex-specific oxidative stress reactivity in the epidermis.
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