Cognitive deficits in older adults with mild cognitive impairment in a two-year follow-up study

Camila de Assis Faria1, Heloisa Veiga Dias Alves1, Eduarda Naidel Barboza E Barbosa1

  • 1MD. Pontifícia Universidade Católica do Rio de Janeiro, RJ, Brazil.

Insights

Cognitive decline in mild cognitive impairment (MCI) predicts dementia conversion. Declines in multiple cognitive functions, not just executive functions, increased dementia risk and depressive symptoms in older adults.

Area of Science:

  • Neurology
  • Geriatrics
  • Neuropsychology

Background:

  • Characterizing cognitive decline in older adults with mild cognitive impairment (MCI) is crucial for identifying conversion to dementia.
  • Understanding cognitive trajectories in MCI is essential for early intervention strategies.

Purpose of the Study:

  • To examine the two-year cognitive trajectory of elderly adults diagnosed with MCI.
  • To identify distinct cognitive decline profiles and their association with dementia conversion and depressive symptoms.

Main Methods:

  • A cohort of 62 older adults with MCI was assessed using a neuropsychological battery.
  • Participants were re-evaluated after two years to track cognitive changes.
  • Statistical analyses, including the Mann-Whitney U test, compared groups based on cognitive decline, education, functioning, and depression.

Main Results:

  • 24.2% of individuals with MCI converted to dementia within two years.
  • A decline in two or more cognitive functions was associated with a higher conversion rate to dementia compared to executive function decline alone (p = .04).
  • The executive function decline group reported higher depression scores than memory decline and multiple decline groups (p < .05).

Conclusions:

  • Distinct cognitive decline profiles exist in older adults with MCI.
  • These profiles are associated with varying rates of conversion to dementia and differences in depressive symptoms.

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