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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Antimicrobial resistance mechanisms and potential synthetic treatments

Junaid Ali1,1, Qasim A Rafiq2,2, Elizabeth Ratcliffe1,1

  • 1Department of Chemical Engineering, Centre for Biological Engineering, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK.

Future Science OA
|April 24, 2018
PubMed

Insights

Antibiotic resistance is a growing global threat. Novel strategies like organism re-engineering and gene editing, including CRISPR-Cas9, offer promising solutions to combat resistant bacteria.

Area of Science:

  • Microbiology
  • Genetics
  • Biotechnology

Background:

  • Antibiotics are crucial for treating bacterial infections but their efficacy is threatened by widespread antibiotic resistance.
  • Bacterial resistance to antimicrobial agents is a significant global health concern affecting both human and animal populations.
  • Resistance can emerge rapidly, sometimes within a year of a new antimicrobial's introduction.

Purpose of the Study:

  • To review the mechanisms underlying antibiotic resistance.
  • To examine novel and innovative technologies for combating antibiotic resistance.
  • To explore strategies such as organism re-engineering, bacterial re-sensitization, and gene editing.

Main Methods:

  • Literature review of scientific articles and research papers on antibiotic resistance mechanisms.
  • Analysis of emerging technologies and their potential applications in overcoming resistance.
  • Focus on gene-editing techniques, specifically the clustered regularly interspaced short palindromic repeats-Cas9 (CRISPR-Cas9) system.

Main Results:

  • Identified various mechanisms through which bacteria develop resistance to antibiotics.
  • Highlighted the potential of re-engineering microorganisms to combat resistance.
  • Discussed the application of gene-editing tools like CRISPR-Cas9 as a novel approach.

Conclusions:

  • Antibiotic resistance is a complex challenge requiring innovative solutions.
  • Emerging technologies offer new avenues for developing effective strategies against resistant bacteria.
  • Further research into organism re-engineering and gene editing is crucial for future antimicrobial therapies.
Keywords:
antibioticsantimicrobial resistanceinfectious agentsmolecular biologyre-sensitizingresistance mechanisms

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