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Updated: Feb 11, 2026

Induction of Adhesion-dependent Signals Using Low-intensity Ultrasound
Published on: May 8, 2012
Rac-GTPases and Rac-GEFs in neutrophil adhesion, migration and recruitment
Chiara Pantarelli1, Heidi C E Welch1
1Signalling Programme, Babraham Institute, Cambridge, UK.
Abstract:
Rac-GTPases and their Rac-GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also regulate the effector functions that allow neutrophils to kill bacterial and fungal pathogens, and to clear debris. This review focuses on the roles of Rac-GTPases and Rac-GEFs in neutrophil adhesion, migration and recruitment.
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