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Updated: Feb 11, 2026

Recombineering Homologous Recombination Constructs in Drosophila
Published on: July 13, 2013
Characterization of a Vivid Homolog in Botrytis cinerea
Brandon J Foley1, Haley Stutts1, Sydney L Schmitt1
1Department of Chemistry, Center for Drug Discovery, Design and Delivery, Southern Methodist University, Dallas, TX.
Abstract:
Blue light-signaling pathways regulated by members of the light-oxygen-voltage (LOV) domain family integrate stress responses, circadian rhythms and pathogenesis in fungi. The canonical signaling mechanism involves two LOV-containing proteins that maintain homology to Neurospora crassa Vivid (NcVVD) and White Collar 1 (NcWC1). These proteins engage in homo- and heterodimerization events that modulate gene transcription in response to light. Here, we clone and characterize the VVD homolog in Botrytis cinerea (BcVVD). BcVVD retains divergent photocycle kinetics and is incapable of LOV mediated homodimerization, indicating modification of the classical hetero/homodimerization mechanism of photoadaptation in fungi.
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