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Updated: Feb 11, 2026

Protein Complex Affinity Capture from Cryomilled Mammalian Cells

Protein Complex Affinity Capture from Cryomilled Mammalian Cells

Published on: December 9, 2016

Beryllium Complexes with Bio-Relevant Functional Groups: Coordination Geometries and Binding Affinities.

Matthias Müller¹, Magnus R Buchner¹

¹Anorganische Chemie, Nachwuchsgruppe Berylliumchemie, Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse 4, 35032, Marburg, Germany.

Angewandte Chemie (International Ed. in English)

|April 24, 2018

Summary

This study reveals beryllium (Be²⁺) ion binding affinities to biological functional groups, with carboxylates binding strongest. These findings are crucial for understanding beryllium

Keywords:

beryllium biomimetic carboxylates coordination chemistry macro cycle

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Area of Science:

Inorganic Chemistry
Bioinorganic Chemistry
Structural Chemistry

Background:

The coordination behavior of beryllium (Be²⁺) in biological systems remains largely unknown due to a lack of relevant coordination compounds.
Understanding beryllium's interactions is critical for elucidating its role in biological processes, including immune responses.

Purpose of the Study:

To synthesize and characterize novel beryllium complexes with biologically relevant functional groups.
To determine the binding affinities of Be²⁺ to various ligands, including carboxylates, alcohols, aldehydes, and esters.
To investigate the structural diversity of beryllium coordination compounds.

Main Methods:

Synthesis of beryllium complexes with monodentate carboxylic acids, esters, aldehydes, and alcohols.
Solution and solid-state characterization techniques.
X-ray crystallography for structural determination.

Main Results:

Established the binding affinity order for Be²⁺: carboxylate > alcohol > aldehyde > ester.
Determined crystal structures for all synthesized beryllium compounds.
Reported the first dodeca-nuclear macrocyclic ring structure of a beryllium carboxylate complex.

Conclusions:

Provides foundational data on beryllium coordination chemistry with bio-relevant ligands.
Enables prediction of potential beryllium binding sites within protein environments.
Contributes to understanding the mechanisms underlying beryllium-mediated biological effects.